Talipexole dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Talipexole diHClide 是大鼠皮质和肠膜组分中的多巴胺 D2 受体激动剂、α2-肾上腺素受体激动剂和 5-HT3 受体拮抗剂，Ki 值分别为 0.35 μM 和 0.22 μM。它显示出抗帕金森病活性。

Talipexole dihydrochloride is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.(In Vivo):Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate.

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Intravenous injection of 30 micrograms/kg of Talipexole dihydrochloride (B-HT 920) into cats lead initially to an increase in blood pressure and then to a long-lasting decrease in blood pressure and heart rate. Vagally mediated reflex bradycardia elicited by angiotensin injection in beta-adrenoceptor-blocked dogs was facilitated by intracisternal injection of 10 micrograms/kg Talipexole dihydrochloride (B-HT 920).

B-HT 920 dihydrochloride | Domnin

GPCR/G Protein

Dopamine Receptor

PARP1| PARP2

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36085-73-1

282.23

C10H17Cl2N3S

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (88.58 mM)

Cl.Cl.Nc1nc2CCN(CC=C)CCc2s1

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(-20℃)

With Ice Pack

≥ 2 years